| Players Picked at #50 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2025 | 50 | Seattle Seahawks | Elijah Arroyo | TE | Miami (FL) | |||||
| 2024 | 50 | Washington Commanders | Mike Sainristil | CB | Michigan | |||||
| 2023 | 50 | Green Bay Packers | Jayden Reed | WR | Michigan State | |||||
| 2022 | 50 | New England Patriots | Tyquan Thornton | WR | Baylor | |||||
| 2021 | 50 | New York Giants | Azeez Ojulari | DE | Georgia | |||||
| 2020 | 50 | Chicago Bears | Jaylon Johnson | DB | Utah | |||||
| 2019 | 50 | Minnesota Vikings | Irv Smith Jr. | TE | Alabama | |||||
| 2018 | 50 | Dallas Cowboys | Connor Williams | T | Texas | |||||
| 2017 | 50 | Tampa Bay Buccaneers | Justin Evans | S | Texas A&M | |||||
| 2016 | 50 | Houston Texans | Nick Martin | C | Notre Dame | |||||
| 2015 | 50 | Buffalo Bills | Ronald Darby | CB | Florida State | |||||
| 2014 | 50 | San Diego Chargers | Jeremiah Attaochu | LB | Georgia Tech | |||||
| 2013 | 50 | Chicago Bears | Jonathan Bostic | LB | Florida | |||||
| 2012 | 50 | St Louis Rams | Isaiah Pead | RB | Cincinnati | |||||
| 2011 | 50 | San Diego Chargers | Marcus Gilchrist | CB | Clemson | |||||
| 2010 | 50 | Kansas City Chiefs | Javier Arenas | CB | Alabama | |||||
| 2009 | 50 | Cleveland Browns | Mohamed Massaquoi | WR | Georgia | |||||
| 2008 | 50 | Arizona Cardinals | Calais Campbell | DE | Miami (FL) | |||||
| 2007 | 50 | Tennessee Titans | Chris Henry | RB | Arizona | |||||
| 2006 | 50 | San Diego Chargers | Marcus McNeill | T | Auburn | |||||
| 2005 | 50 | St Louis Rams | Ron Bartell | CB | Howard | |||||
| 2004 | 50 | New Orleans Saints | Devery Henderson | WR | LSU | |||||
| 2003 | 50 | Carolina Panthers | Bruce Nelson | C | Iowa | |||||
| 2002 | 50 | Houston Texans | Chester Pitts | G | San Diego State | |||||
| 2001 | 50 | Detroit Lions | Dominic Raiola | C | Nebraska | |||||
| 2000 | 50 | Detroit Lions | Barrett Green | LB | West Virginia | |||||
| 1999 | 50 | Tampa Bay Buccaneers | Shaun King | QB | Tulane | |||||
| 1998 | 50 | Detroit Lions | Germane Crowell | WR | Virginia | |||||
| 1997 | 50 | Jacksonville Jaguars | Mike Logan | CB | West Virginia | |||||
| 1996 | 50 | San Diego Chargers | Patrick Sapp | LB | Clemson | |||||
| 1995 | 50 | Philadelphia Eagles | Bobby Taylor | CB | Notre Dame | |||||
| 1994 | 50 | Pittsburgh Steelers | Brentson Buckner | DE | Clemson | |||||
| 1993 | 50 | Philadelphia Eagles | Victor Bailey | WR | Missouri | |||||
| 1992 | 50 | Houston Oilers | Eddie Robinson | LB | Alabama State | |||||
| 1991 | 50 | Kansas City Chiefs | Joe Valerio | T | Pennsylvania | |||||
| 1990 | 50 | Philadelphia Eagles | Mike Bellamy | WR | Illinois | |||||
| 1989 | 50 | Houston Oilers | Scott Kozak | LB | Oregon | |||||
| 1988 | 50 | Cleveland Browns | Michael Dean Perry | DT | Clemson | |||||
| 1987 | 50 | Tampa Bay Buccaneers | Winston Moss | LB | Miami (FL) | |||||
| 1986 | 50 | Los Angeles Rams | Tom Newberry | G | Wisconsin-LaCrosse | |||||
| 1985 | 50 | Los Angeles Rams | Chuck Scott | WR | Vanderbilt | |||||
| 1984 | 50 | Cleveland Browns | Bruce Davis | WR | Baylor | |||||
| 1983 | 50 | Dallas Cowboys | Mike Walter | LB | Oregon | |||||
| 1982 | 50 | Denver Broncos | Orlando McDaniel | WR | LSU | |||||
| 1981 | 50 | Buffalo Bills | Byron Franklin | WR | Auburn | |||||
| 1980 | 50 | Los Angeles Rams | Irv Pankey | T | Penn State | |||||
| 1979 | 50 | Houston Oilers | Jesse Baker | DE | Jackson State | |||||
| 1978 | 50 | New England Patriots | Matt Cavanaugh | QB | Pittsburgh | |||||
| 1977 | 50 | Los Angeles Rams | Billy Waddy | RB | Colorado | |||||
| 1976 | 50 | Oakland Raiders | Jeb Blount | QB | Tulsa | |||||
| 1975 | 50 | Buffalo Bills | Glenn Loft | DB | Drake | |||||
| 1974 | 50 | Los Angeles Rams | Bill Simpson | DB | Michigan State | |||||
| 1973 | 50 | Pittsburgh Steelers | Ken Phares | DB | Mississippi State | |||||
| 1972 | 50 | Minnesota Vikings | Ed Marinaro | RB | Cornell | |||||
| 1971 | 50 | Philadelphia Eagles | Hank Allison | G | San Diego State | |||||
| 1970 | 50 | Oakland Raiders | Ted Koy | TE | Texas | |||||
| 1969 | 50 | Oakland Raiders | George Buehler | G | Stanford | |||||
| 1968 | 50 | Baltimore Colts | Bob Grant | LB | Wake Forest | |||||
| 1967 | 50 | Kansas City Chiefs | Willie Lanier | LB | Morgan State | HOF - 1986 | ||||
| 1966 | 50 | Los Angeles Rams | Henry Dyer | RB | Grambling State | |||||
| 1965 | 50 | Los Angeles Rams | Mike Strofolino | LB | Villanova | |||||
| 1964 | 50 | Baltimore Colts | Ted Davis | E | Georgia Tech | |||||
| 1963 | 50 | San Francisco 49ers | Hugh Campbell | E | Washington State | |||||
| 1962 | 50 | San Francisco 49ers | Floyd Dean | T | Florida | |||||
| 1961 | 50 | St. Louis Cardinals | Ron McDole | T | Nebraska | |||||
| 1960 | 50 | St. Louis Cardinals | Bill Burrell | LB | Illinois | |||||
| 1959 | 50 | Chicago Cardinals | Maury Schleicher | E | Penn State | |||||
| 1958 | 50 | Baltimore Colts | Ray Brown | B | Mississippi | |||||
| 1957 | 50 | Philadelphia Eagles | Jimmy Harris | QB | Oklahoma | |||||
| 1956 | 50 | Detroit Lions | Tom Tracy | B | Tennessee | |||||
| 1955 | 50 | Chicago Cardinals | Mario Da Re | T | USC | |||||
| 1954 | 50 | Chicago Cardinals | Don Dohoney | E | Michigan State | |||||
| 1953 | 50 | Baltimore Colts | Jack Little | T | Texas A&M | |||||
| 1952 | 50 | Dallas Texans | Jack Jorgenson | T | Colorado | |||||
| 1951 | 50 | Cleveland Browns | Art Donovan | T | Boston College | |||||
| 1950 | 50 | Chicago Bears | Dom Papaleo | G | Boston College | |||||
| 1949 | 50 | Chicago Cardinals | Tom Wham | E | Furman | |||||
| 1948 | 50 | Los Angeles Rams | Noel Cudd | T | West Texas State | |||||
| 1947 | 50 | Chicago Cardinals | Howard Turner | B | North Carolina State | |||||
| 1946 | 50 | Los Angeles Rams | Newell Oestreich | B | California | |||||
| 1945 | 50 | Chicago Bears | Wayne Shaw | B | SMU | |||||
| 1944 | 50 | Washington Redskins | Jackie Fellows | B | Fresno State | |||||
| 1943 | 50 | Washington Redskins | Wally Ziemba | C | Notre Dame | |||||
| 1942 | 50 | Chicago Bears | H.C. Burrus | E | Hardin-Simmons | |||||
| 1941 | 50 | Washington Redskins | Ed Cifers | E | Tennessee | |||||
| 1940 | 50 | New York Giants | Lou Smith | B | California | |||||
| 1939 | 50 | New York Giants | Jerry Ginney | G | Santa Clara | |||||
| 1938 | 50 | Chicago Bears | Bob Masterson | E | Miami (FL) | |||||
| 1937 | 50 | Cleveland Rams | Inwood Smith | T | Ohio State | |||||
| 1936 | 50 | Chicago Bears | Ted Christofferson | B | Washington State | |||||
