| Players Picked at #4 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2025 | 4 | New England Patriots | Will Campbell | T | LSU | |||||
| 2024 | 4 | Arizona Cardinals | Marvin Harrison Jr. | WR | Ohio State | |||||
| 2023 | 4 | Indianapolis Colts | Anthony Richardson | QB | Florida | |||||
| 2022 | 4 | New York Jets | Sauce Gardner | CB | Cincinnati | |||||
| 2021 | 4 | Atlanta Falcons | Kyle Pitts | TE | Florida | |||||
| 2020 | 4 | New York Giants | Andrew Thomas | OL | Georgia | |||||
| 2019 | 4 | Oakland Raiders | Clelin Ferrell | DE | Clemson | |||||
| 2018 | 4 | Cleveland Browns | Denzel Ward | CB | Ohio State | |||||
| 2017 | 4 | Jacksonville Jaguars | Leonard Fournette | RB | LSU | |||||
| 2016 | 4 | Dallas Cowboys | Ezekiel Elliott | RB | Ohio State | |||||
| 2015 | 4 | Oakland Raiders | Amari Cooper | WR | Alabama | |||||
| 2014 | 4 | Buffalo Bills | Sammy Watkins | WR | Clemson | |||||
| 2013 | 4 | Philadelphia Eagles | Lane Johnson | T | Oklahoma | |||||
| 2012 | 4 | Minnesota Vikings | Matt Kalil | T | USC | |||||
| 2011 | 4 | Cincinnati Bengals | A.J. Green | WR | Georgia | |||||
| 2010 | 4 | Washington Redskins | Trent Williams | T | Oklahoma | |||||
| 2009 | 4 | Seattle Seahawks | Aaron Curry | LB | Wake Forest | |||||
| 2008 | 4 | Oakland Raiders | Darren McFadden | RB | Arkansas | |||||
| 2007 | 4 | Tampa Bay Buccaneers | Gaines Adams | DE | Clemson | |||||
| 2006 | 4 | New York Jets | D'Brickashaw Ferguson | T | Virginia | |||||
| 2005 | 4 | Chicago Bears | Cedric Benson | RB | Texas | |||||
| 2004 | 4 | New York Giants | Philip Rivers | QB | North Carolina State | |||||
| 2003 | 4 | New York Jets | Dewayne Robertson | DT | Kentucky | |||||
| 2002 | 4 | Buffalo Bills | Mike Williams | T | Texas | |||||
| 2001 | 4 | Cincinnati Bengals | Justin Smith | DE | Missouri | |||||
| 2000 | 4 | Cincinnati Bengals | Peter Warrick | WR | Florida State | |||||
| 1999 | 4 | Indianapolis Colts | Edgerrin James | RB | Miami (FL) | HOF - 2020 | ||||
| 1998 | 4 | Oakland Raiders | Charles Woodson | CB | Michigan | HOF - 2021 | ||||
| 1997 | 4 | Baltimore Ravens | Peter Boulware | LB | Florida State | |||||
| 1996 | 4 | Baltimore Ravens | Jonathan Ogden | T | UCLA | HOF - 2013 | ||||
| 1995 | 4 | Washington Redskins | Michael Westbrook | WR | Colorado | |||||
| 1994 | 4 | New England Patriots | Willie McGinest | LB | USC | |||||
| 1993 | 4 | New York Jets | Marvin Jones | LB | Florida State | |||||
| 1992 | 4 | Washington Redskins | Desmond Howard | WR | Michigan | |||||
| 1991 | 4 | Denver Broncos | Mike Croel | LB | Nebraska | |||||
| 1990 | 4 | Tampa Bay Buccaneers | Keith McCants | LB | Alabama | |||||
| 1989 | 4 | Kansas City Chiefs | Derrick Thomas | LB | Alabama | HOF - 2009 | ||||
| 1988 | 4 | Tampa Bay Buccaneers | Paul Gruber | T | Wisconsin | |||||
| 1987 | 4 | Green Bay Packers | Brent Fullwood | RB | Auburn | |||||
| 1986 | 4 | Indianapolis Colts | Jon Hand | DE | Alabama | |||||
| 1985 | 4 | Minnesota Vikings | Chris Doleman | DE | Pittsburgh | HOF - 2012 | ||||
| 1984 | 4 | Philadelphia Eagles | Kenny Jackson | WR | Penn State | |||||
| 1983 | 4 | Denver Broncos | Chris Hinton | G | Northwestern | |||||
| 1982 | 4 | Baltimore Colts | Art Schlichter | QB | Ohio State | |||||
| 1981 | 4 | Seattle Seahawks | Kenny Easley | S | UCLA | HOF - 2017 | ||||
| 1980 | 4 | Green Bay Packers | Bruce Clark | DE | Penn State | |||||
| 1979 | 4 | Chicago Bears | Dan Hampton | DT | Arkansas | HOF - 2002 | ||||
| 1978 | 4 | New York Jets | Chris Ward | T | Ohio State | |||||
| 1977 | 4 | New York Jets | Marvin Powell | T | USC | |||||
| 1976 | 4 | San Diego Chargers | Joe Washington | RB | Oklahoma | |||||
| 1975 | 4 | Chicago Bears | Walter Payton | RB | Jackson State | HOF - 1993 | ||||
| 1974 | 4 | Chicago Bears | Waymond Bryant | LB | Tennessee State | |||||
| 1973 | 4 | New England Patriots | John Hannah | G | Alabama | HOF - 1991 | ||||
| 1972 | 4 | St. Louis Cardinals | Bobby Moore | WR | Oregon | |||||
| 1971 | 4 | Buffalo Bills | J.D. Hill | WR | Arizona State | |||||
| 1970 | 4 | Boston Patriots | Phil Olsen | DT | Utah State | |||||
| 1969 | 4 | Pittsburgh Steelers | Joe Greene | DT | North Texas | HOF - 1987 | ||||
| 1968 | 4 | San Diego Chargers | Russ Washington | T | Missouri | |||||
| 1967 | 4 | Miami Dolphins | Bob Griese | QB | Purdue | HOF - 1990 | ||||
| 1966 | 4 | Philadelphia Eagles | Randy Beisler | DE | Indiana | |||||
| 1965 | 4 | Chicago Bears | Gale Sayers | HB | Kansas | HOF - 1977 | ||||
| 1964 | 4 | Dallas Cowboys | Scott Appleton | T | Texas | |||||
| 1963 | 4 | Philadelphia Eagles | Ed Budde | T | Michigan State | |||||
| 1962 | 4 | Cleveland Browns | Gary Collins | E | Maryland | |||||
| 1961 | 4 | Los Angeles Rams | Marlin McKeever | LB | USC | |||||
| 1960 | 4 | Washington Redskins | Richie Lucas | QB | Penn State | |||||
| 1959 | 4 | Washington Redskins | Don Allard | QB | Boston College | |||||
| 1958 | 4 | Los Angeles Rams | Lou Michaels | DT | Kentucky | |||||
| 1957 | 4 | Green Bay Packers | Ron Kramer | E | Michigan | |||||
| 1956 | 4 | Philadelphia Eagles | Bob Pellegrini | C | Maryland | |||||
| 1955 | 4 | Washington Redskins | Ralph Guglielmi | QB | Notre Dame | |||||
| 1954 | 4 | Green Bay Packers | Veryl Switzer | HB | Kansas State | |||||
| 1953 | 4 | Chicago Cardinals | Johnny Olszewski | FB | California | |||||
| 1952 | 4 | Green Bay Packers | Vito Parilli | QB | Kentucky | |||||
| 1951 | 4 | Washington Redskins | Leon Heath | FB | Oklahoma | |||||
| 1950 | 4 | Green Bay Packers | Clayton Tonnemaker | OLB | Minnesota | |||||
| 1949 | 4 | New York Giants | Paul Page | HB | SMU | |||||
| 1948 | 4 | Washington Redskins | Lowell Tew | B | Alabama | |||||
| 1947 | 4 | Washington Redskins | Cal Rossi | B | UCLA | |||||
| 1946 | 4 | Chicago Bears | Johnny Lujack | QB | Notre Dame | |||||
| 1945 | 4 | The Yanks | Eddie Prokop | B | Georgia Tech | |||||
| 1944 | 4 | Detroit Lions | Otto Graham | B | Northwestern | HOF - 1965 | ||||
| 1943 | 4 | Brooklyn Dodgers | Paul Governali | QB | Columbia | |||||
| 1942 | 4 | Chicago Cardinals | Steve Lach | FB | Duke | |||||
| 1941 | 4 | Cleveland Rams | Rudy Mucha | C | Washington | |||||
| 1940 | 4 | Brooklyn Dodgers | Banks McFadden | HB | Clemson | |||||
| 1939 | 4 | Philadelphia Eagles | Davey O'Brien | QB | TCU | |||||
| 1938 | 4 | Pittsburgh Pirates | Byron White | B | Colorado | |||||
| 1937 | 4 | New York Giants | Ed Widseth | B | Minnesota | |||||
| 1936 | 4 | Brooklyn Dodgers | Dick Crayne | FB | Iowa | |||||
NFL Draft - Overall Pick #4 Only