| Players Picked at #251 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2025 | 251 | New England Patriots | Julian Ashby | LS | Vanderbilt | |||||
| 2024 | 251 | San Francisco 49ers | Tatum Bethune | LB | Florida State | |||||
| 2023 | 251 | Pittsburgh Steelers | Spencer Anderson | G | Maryland | |||||
| 2022 | 251 | Kansas City Chiefs | Isaih Pacheco | RB | Rutgers | |||||
| 2021 | 251 | Tampa Bay Buccaneers | Chris Wilcox | CB | BYU | |||||
| 2020 | 251 | Seattle Seahawks | Stephen Sullivan | TE | LSU | |||||
| 2019 | 251 | Los Angeles Rams | Dakota Allen | LB | Texas Tech | |||||
| 2018 | 251 | Los Angeles Chargers | Justin Jackson | RB | Northwestern | |||||
| 2017 | 251 | Cincinnati Bengals | Mason Schreck | TE | Buffalo | |||||
| 2016 | 251 | Philadelphia Eagles | Joe Walker | ILB | Oregon | |||||
| 2015 | 251 | Denver Broncos | Taurean Nixon | CB | Tulane | |||||
| 2014 | 251 | Dallas Cowboys | Ken Bishop | DT | NIU | |||||
| 2013 | 251 | Cincinnati Bengals | T.J. Johnson | C | South Carolina | |||||
| 2012 | 251 | Buffalo Bills | John Potter | K | Western Michigan | |||||
| 2011 | 251 | Tennessee Titans | Tommie Campbell | CB | California (PA) | |||||
| 2010 | 251 | Oakland Raiders | Stevie Brown | S | Michigan | |||||
| 2009 | 251 | Chicago Bears | Derek Kinder | WR | Pittsburgh | |||||
| 2008 | 251 | Buffalo Bills | Kennard Cox | CB | Pittsburgh | |||||
| 2007 | 251 | Jacksonville Jaguars | Chad Nkang | LB | Elon | |||||
| 2006 | 251 | Houston Texans | David Anderson | WR | Colorado State | |||||
| 2005 | 251 | St Louis Rams | Madison Hedgecock | FB | North Carolina | |||||
| 2004 | 251 | Green Bay Packers | Scott Wells | C | Tennessee | |||||
| 2003 | 251 | St Louis Rams | Scott Shanle | LB | Nebraska | |||||
| 2002 | 251 | Buffalo Bills | Jarrett Ferguson | RB | Virginia Tech | |||||
| 2000 | 251 | Buffalo Bills | DaShon Polk | LB | Arizona | |||||
| 1999 | 251 | Philadelphia Eagles | Pernell Davis | DT | Alabama Birmingham | |||||
| 1996 | 251 | Miami Dolphins | Brice Hunter | WR | Georgia | |||||
| 1992 | 251 | Buffalo Bills | Chris Walsh | WR | Stanford | |||||
| 1991 | 251 | New England Patriots | Randy Bethel | TE | Miami (FL) | |||||
| 1990 | 251 | New York Jets | Brad Quast | LB | Iowa | |||||
| 1989 | 251 | San Francisco 49ers | Rudy Harmon | LB | LSU | |||||
| 1988 | 251 | Kansas City Chiefs | Kenny Gamble | RB | Colgate | |||||
| 1987 | 251 | New York Giants | Dana Wright | RB | Findlay | |||||
| 1986 | 251 | Buffalo Bills | Guy Teafatiller | DT | Illinois | |||||
| 1985 | 251 | Miami Dolphins | Adam Hinds | DB | Oklahoma State | |||||
| 1984 | 251 | New England Patriots | David Windham | LB | Jackson State | |||||
| 1983 | 251 | Washington Redskins | Marcus Gilbert | RB | TCU | |||||
| 1982 | 251 | San Francisco 49ers | Bryan Clark | QB | Michigan State | |||||
| 1981 | 251 | New York Jets | Marty Wetzel | LB | Tulane | |||||
| 1980 | 251 | Detroit Lions | Henry Henderson | DB | Utah State | |||||
| 1979 | 251 | Kansas City Chiefs | Mike DuPree | LB | Florida | |||||
| 1978 | 251 | Kansas City Chiefs | Earl Bryant | DE | Jackson State | |||||
| 1977 | 251 | Tampa Bay Buccaneers | Larry Mucker | WR | Arizona State | |||||
| 1976 | 251 | San Diego Chargers | Glynn Harrison | RB | Georgia | |||||
| 1975 | 251 | Denver Broncos | Steve Haggerty | WR | UNLV | |||||
| 1974 | 251 | St. Louis Cardinals | Greg Hartle | LB | Newberry College | |||||
| 1973 | 251 | Kansas City Chiefs | Willie Osley | DB | Illinois | |||||
| 1972 | 251 | Los Angeles Rams | Jim Massey | DB | Linfield (OR) | |||||
| 1971 | 251 | St. Louis Cardinals | Ronald Miller | T | McNeese State | |||||
| 1970 | 251 | Green Bay Packers | Frank Patrick | QB | Nebraska | |||||
| 1969 | 251 | San Diego Chargers | David Arnold | G | Northwestern State | |||||
| 1968 | 251 | Buffalo Bills | Jerome Lawson | DB | Utah | |||||
| 1967 | 251 | San Diego Chargers | Torre Ossmo | T | Western Michigan | |||||
| 1966 | 251 | Washington Redskins | Mitch Zalnasky | WR | Pittsburgh | |||||
| 1965 | 251 | Cleveland Browns | Dick Arrington | G | Notre Dame | |||||
| 1964 | 251 | Green Bay Packers | Mike Hicks | G | Marshall | |||||
| 1963 | 251 | Detroit Lions | Al Greer | E | Jackson State | |||||
| 1962 | 251 | Philadelphia Eagles | Tom Larscheid | B | Utah State | |||||
| 1961 | 251 | Cleveland Browns | Ed Morris | T | Indiana | |||||
| 1959 | 251 | New York Giants | Fred Swearingen | G | North Carolina | |||||
| 1958 | 251 | San Francisco 49ers | Don Christian | B | Arkansas | |||||
| 1957 | 251 | Detroit Lions | Dudley Meredith | T | Lamar | |||||
| 1956 | 251 | Washington Redskins | Howard Schnellenberger | E | Kentucky | |||||
| 1955 | 251 | Chicago Bears | Choyce Hall | C | Midwestern State (TX) | |||||
| 1954 | 251 | San Francisco 49ers | Howard Alsup | T | Middle Tennessee State | |||||
| 1953 | 251 | Cleveland Browns | Bill Crockett | G | Rice | |||||
| 1952 | 251 | New York Giants | Jim Creamer | C | Michigan State | |||||
| 1951 | 251 | New York Yanks | Al Pollard | B | Army | |||||
| 1950 | 251 | Green Bay Packers | Jim Howe | B | Kentucky | |||||
| 1949 | 251 | Philadelphia Eagles | John Schweder | G | Pennsylvania | |||||
| 1948 | 251 | Green Bay Packers | Stan Gorski | E | St. Mary's (MN) | |||||
| 1947 | 251 | Philadelphia Eagles | Phil Cutchin | B | Kentucky | |||||
| 1946 | 251 | Chicago Cardinals | Jesse Herschbarger | E | SMU | |||||
| 1945 | 251 | New York Giants | Vince Mroz | E | Michigan State | |||||
| 1944 | 251 | Cleveland Rams | Joe Warlick | B | Mississippi State | |||||
| 1943 | 251 | Detroit Lions | Chuck Fears | T | UCLA | |||||
NFL Draft - Overall Pick #251 Only