| Players Picked at #22 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2025 | 22 | Los Angeles Chargers | Omarion Hampton | RB | North Carolina | |||||
| 2024 | 22 | Philadelphia Eagles | Quinyon Mitchell | CB | Toledo | |||||
| 2023 | 22 | Baltimore Ravens | Zay Flowers | WR | Boston College | |||||
| 2022 | 22 | Green Bay Packers | Quay Walker | LB | Georgia | |||||
| 2021 | 22 | Tennessee Titans | Caleb Farley | CB | Virginia Tech | |||||
| 2020 | 22 | Minnesota Vikings | Justin Jefferson | WR | LSU | |||||
| 2019 | 22 | Philadelphia Eagles | Andre Dillard | T | Washington State | |||||
| 2018 | 22 | Tennessee Titans | Rashaan Evans | LB | Alabama | |||||
| 2017 | 22 | Miami Dolphins | Charles Harris | OLB | Missouri | |||||
| 2016 | 22 | Washington Redskins | Josh Doctson | WR | TCU | |||||
| 2015 | 22 | Pittsburgh Steelers | Bud Dupree | OLB | Kentucky | |||||
| 2014 | 22 | Cleveland Browns | Johnny Manziel | QB | Texas A&M | |||||
| 2013 | 22 | Atlanta Falcons | Desmond Trufant | CB | Washington | |||||
| 2012 | 22 | Cleveland Browns | Brandon Weeden | QB | Oklahoma State | |||||
| 2011 | 22 | Indianapolis Colts | Anthony Castonzo | T | Boston College | |||||
| 2010 | 22 | Denver Broncos | Demaryius Thomas | WR | Georgia Tech | |||||
| 2009 | 22 | Minnesota Vikings | Percy Harvin | WR | Florida | |||||
| 2008 | 22 | Dallas Cowboys | Felix Jones | RB | Arkansas | |||||
| 2007 | 22 | Cleveland Browns | Brady Quinn | QB | Notre Dame | |||||
| 2006 | 22 | San Francisco 49ers | Manny Lawson | LB | North Carolina State | |||||
| 2005 | 22 | Baltimore Ravens | Mark Clayton | WR | Oklahoma | |||||
| 2004 | 22 | Buffalo Bills | J.P. Losman | QB | Tulane | |||||
| 2003 | 22 | Chicago Bears | Rex Grossman | QB | Florida | |||||
| 2002 | 22 | New York Jets | Bryan Thomas | DE | Alabama Birmingham | |||||
| 2001 | 22 | New York Giants | Will Allen | CB | Syracuse | |||||
| 2000 | 22 | Seattle Seahawks | Chris McIntosh | T | Wisconsin | |||||
| 1999 | 22 | Seattle Seahawks | Lamar King | DE | Saginaw Valley State | |||||
| 1998 | 22 | New England Patriots | Tebucky Jones | S | Syracuse | |||||
| 1997 | 22 | Dallas Cowboys | David LaFleur | TE | LSU | |||||
| 1996 | 22 | Tampa Bay Buccaneers | Marcus Jones | DE | North Carolina | |||||
| 1995 | 22 | Carolina Panthers | Tyrone Poole | CB | Fort Valley State | |||||
| 1994 | 22 | Los Angeles Raiders | Rob Fredrickson | LB | Michigan State | |||||
| 1993 | 22 | San Diego Chargers | Darrien Gordon | CB | Stanford | |||||
| 1992 | 22 | Chicago Bears | Alonzo Spellman | DE | Ohio State | |||||
| 1991 | 22 | Chicago Bears | Stan Thomas | T | Texas | |||||
| 1990 | 22 | Philadelphia Eagles | Ben Smith | CB | Georgia | |||||
| 1989 | 22 | Indianapolis Colts | Andre Rison | WR | Michigan State | |||||
| 1988 | 22 | Houston Oilers | Lorenzo White | RB | Michigan State | |||||
| 1987 | 22 | San Francisco 49ers | Harris Barton | T | North Carolina | |||||
| 1986 | 22 | New York Jets | Mike Haight | T | Iowa | |||||
| 1985 | 22 | Chicago Bears | William Perry | DT | Clemson | |||||
| 1984 | 22 | Seattle Seahawks | Terry Taylor | CB | Southern Illinois | |||||
| 1983 | 22 | San Diego Chargers | Gill Byrd | CB | San Jose State | |||||
| 1982 | 22 | Green Bay Packers | Ron Hallstrom | G | Iowa Central | |||||
| 1981 | 22 | Cleveland Browns | Hanford Dixon | CB | Southern Mississippi | |||||
| 1980 | 22 | Tampa Bay Buccaneers | Ray Snell | G | Wisconsin | |||||
| 1979 | 22 | Denver Broncos | Kelvin Clark | T | Nebraska | |||||
| 1978 | 22 | Pittsburgh Steelers | Ron Johnson | CB | Eastern Michigan | |||||
| 1977 | 22 | Cincinnati Bengals | Mike Cobb | TE | Michigan State | |||||
| 1976 | 22 | St. Louis Cardinals | Mike Dawson | DT | Arizona | |||||
| 1975 | 22 | San Diego Chargers | Mike Williams | CB | LSU | |||||
| 1974 | 22 | Dallas Cowboys | Charley Young | RB | North Carolina State | |||||
| 1973 | 22 | Cleveland Browns | Pete Adams | T | USC | |||||
| 1972 | 22 | Baltimore Colts | Tom Drougas | T | Oregon | |||||
| 1971 | 22 | Baltimore Colts | Don McCauley | RB | North Carolina | |||||
| 1970 | 22 | Los Angeles Rams | Jack Reynolds | LB | Tennessee | |||||
| 1969 | 22 | Oakland Raiders | Art Thoms | DT | Syracuse | |||||
| 1968 | 22 | Kansas City Chiefs | George Daney | G | UTEP | |||||
| 1967 | 22 | Buffalo Bills | John Pitts | DB | Arizona State | |||||
| 1966 | 22 | Dallas Cowboys | Willie Townes | T | Tulsa | |||||
| 1965 | 22 | Cleveland Browns | Gerry Bussell | RB | Georgia Tech | |||||
| 1964 | 22 | Baltimore Colts | Tony Lorick | RB | Arizona State | |||||
| 1963 | 22 | Washington Redskins | Lonnie Sanders | CB | Michigan State | |||||
| 1962 | 22 | San Francisco 49ers | Ed Pine | C | Utah | |||||
| 1961 | 22 | St. Louis Cardinals | Fred Arbanas | E | Michigan State | |||||
| 1960 | 22 | San Francisco 49ers | Carl Kammerer | G | Pacific | |||||
| 1959 | 22 | New York Giants | Buddy Dial | E | Rice | |||||
| 1958 | 22 | San Francisco 49ers | Bob Newman | B | Washington State | |||||
| 1957 | 22 | Chicago Cardinals | Tom Maentz | E | Michigan | |||||
| 1956 | 22 | Chicago Bears | M.L. Brackett | T | Auburn | |||||
| 1955 | 22 | Philadelphia Eagles | Alex Lansford | T | Texas | |||||
| 1954 | 22 | Los Angeles Rams | Buddy Gillioz | T | Houston | |||||
| 1953 | 22 | New York Giants | Eddie Crowder | QB | Oklahoma | |||||
| 1952 | 22 | San Francisco 49ers | Bob Toneff | T | Notre Dame | |||||
| 1951 | 22 | New York Yanks | Ken Jackson | T | Texas | |||||
| 1950 | 22 | Pittsburgh Steelers | Ernie Stautner | DT | Boston College | HOF - 1969 | ||||
| 1949 | 22 | Detroit Lions | Lou Kusserow | B | Columbia | |||||
| 1948 | 22 | Philadelphia Eagles | Paul Campbell | QB | Texas | |||||
| 1947 | 22 | New York Giants | John Cannady | C | Indiana | |||||
| 1946 | 22 | Detroit Lions | Russ Thomas | T | Ohio State | |||||
| 1945 | 22 | Chicago Bears | Charley Allen | B | SMU | |||||
| 1944 | 22 | Green Bay Packers | Tom Kuzma | B | Michigan | |||||
| 1943 | 22 | Pittsburgh Steelers | Jack Russell | E | Baylor | |||||
| 1942 | 22 | Brooklyn Dodgers | Curt Mecham | B | Oregon | |||||
| 1941 | 22 | New York Giants | Frank Reagan | B | Pennsylvania | |||||
| 1940 | 22 | Chicago Bears | Ken Kavanaugh | E | LSU | |||||
| 1939 | 22 | Detroit Lions | Howie Weiss | FB | Wisconsin | |||||
| 1938 | 22 | Green Bay Packers | Marty Schreyer | T | Purdue | |||||
| 1937 | 22 | Brooklyn Dodgers | Max Starcevich | B | Washington | |||||
| 1936 | 22 | Brooklyn Dodgers | Wagner Jorgensen | C | St. Mary's (CA) | |||||
