| Players Picked at #21 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2025 | 21 | Pittsburgh Steelers | Derrick Harmon | DT | Oregon | |||||
| 2024 | 21 | Miami Dolphins | Chop Robinson | DE | Penn State | |||||
| 2023 | 21 | Los Angeles Chargers | Quentin Johnston | WR | TCU | |||||
| 2022 | 21 | Kansas City Chiefs | Trent McDuffie | CB | Washington | |||||
| 2021 | 21 | Indianapolis Colts | Kwity Paye | DE | Michigan | |||||
| 2020 | 21 | Philadelphia Eagles | Jalen Reagor | WR | TCU | |||||
| 2019 | 21 | Green Bay Packers | Darnell Savage Jr. | S | Maryland | |||||
| 2018 | 21 | Cincinnati Bengals | Billy Price | C | Ohio State | |||||
| 2017 | 21 | Detroit Lions | Jarrad Davis | LB | Florida | |||||
| 2016 | 21 | Houston Texans | Will Fuller | WR | Notre Dame | |||||
| 2015 | 21 | Cincinnati Bengals | Cedric Ogbuehi | T | Texas A&M | |||||
| 2014 | 21 | Green Bay Packers | Ha Ha Clinton-Dix | S | Alabama | |||||
| 2013 | 21 | Cincinnati Bengals | Tyler Eifert | TE | Notre Dame | |||||
| 2012 | 21 | New England Patriots | Chandler Jones | DE | Syracuse | |||||
| 2011 | 21 | Cleveland Browns | Phil Taylor | DT | Baylor | |||||
| 2010 | 21 | Cincinnati Bengals | Jermaine Gresham | TE | Oklahoma | |||||
| 2009 | 21 | Cleveland Browns | Alex Mack | C | California | |||||
| 2008 | 21 | Atlanta Falcons | Sam Baker | T | USC | |||||
| 2007 | 21 | Jacksonville Jaguars | Reggie Nelson | S | Florida | |||||
| 2006 | 21 | New England Patriots | Laurence Maroney | RB | Minnesota | |||||
| 2005 | 21 | Jacksonville Jaguars | Matt Jones | WR | Arkansas | |||||
| 2004 | 21 | New England Patriots | Vince Wilfork | NT | Miami (FL) | |||||
| 2003 | 21 | Cleveland Browns | Jeff Faine | C | Notre Dame | |||||
| 2002 | 21 | New England Patriots | Daniel Graham | TE | Colorado | |||||
| 2001 | 21 | Buffalo Bills | Nate Clements | CB | Ohio State | |||||
| 2000 | 21 | Kansas City Chiefs | Sylvester Morris | WR | Jackson State | |||||
| 1999 | 21 | Arizona Cardinals | L.J. Shelton | T | Eastern Michigan | |||||
| 1998 | 21 | Minnesota Vikings | Randy Moss | WR | Marshall | HOF - 2018 | ||||
| 1997 | 21 | Jacksonville Jaguars | Renaldo Wynn | DT | Notre Dame | |||||
| 1996 | 21 | Seattle Seahawks | Pete Kendall | T | Boston College | |||||
| 1995 | 21 | Chicago Bears | Rashaan Salaam | RB | Colorado | |||||
| 1994 | 21 | Detroit Lions | Johnnie Morton | WR | USC | |||||
| 1993 | 21 | Minnesota Vikings | Robert Smith | RB | Ohio State | |||||
| 1992 | 21 | New Orleans Saints | Vaughn Dunbar | RB | Indiana | |||||
| 1991 | 21 | Kansas City Chiefs | Harvey Williams | RB | LSU | |||||
| 1990 | 21 | Pittsburgh Steelers | Eric Green | TE | Liberty | |||||
| 1989 | 21 | Los Angeles Rams | Bill Hawkins | DE | Miami (FL) | |||||
| 1988 | 21 | Cleveland Browns | Clifford Charlton | OLB | Florida | |||||
| 1987 | 21 | New York Jets | Roger Vick | FB | Texas A&M | |||||
| 1986 | 21 | Cincinnati Bengals | Tim McGee | WR | Tennessee | |||||
| 1985 | 21 | Los Angeles Rams | Jerry Gray | CB | Texas | |||||
| 1984 | 21 | Kansas City Chiefs | John Alt | T | Iowa | |||||
| 1983 | 21 | Pittsburgh Steelers | Gabriel Rivera | DT | Texas Tech | |||||
| 1982 | 21 | Denver Broncos | Gerald Willhite | RB | San Jose State | |||||
| 1981 | 21 | Oakland Raiders | Ted Watts | CB | Texas Tech | |||||
| 1980 | 21 | Miami Dolphins | Don McNeal | CB | Alabama | |||||
| 1979 | 21 | Philadelphia Eagles | Jerry Robinson | LB | UCLA | |||||
| 1978 | 21 | Minnesota Vikings | Randy Holloway | DE | Pittsburgh | |||||
| 1977 | 21 | Pittsburgh Steelers | Robin Cole | LB | New Mexico | |||||
| 1976 | 21 | New England Patriots | Tim Fox | S | Ohio State | |||||
| 1975 | 21 | St. Louis Cardinals | Tim Gray | S | Texas A&M | |||||
| 1974 | 21 | Pittsburgh Steelers | Lynn Swann | WR | USC | HOF - 2001 | ||||
| 1973 | 21 | Green Bay Packers | Barry Smith | WR | Florida State | |||||
| 1972 | 21 | Oakland Raiders | Mike Siani | WR | Villanova | |||||
| 1971 | 21 | Detroit Lions | Bob Bell | DT | Cincinnati | |||||
| 1970 | 21 | Cleveland Browns | Bob McKay | T | Texas | |||||
| 1969 | 21 | Los Angeles Rams | Bob Klein | TE | USC | |||||
| 1968 | 21 | Cleveland Browns | Marvin Upshaw | DE | Trinity (TX) | |||||
| 1967 | 21 | Boston Patriots | John Charles | DB | Purdue | |||||
| 1966 | 21 | Washington Redskins | Walter Barnes | T | Nebraska | |||||
| 1965 | 21 | Washington Redskins | Bob Breitenstein | T | Tulsa | |||||
| 1964 | 21 | Chicago Bears | Billy Martin | E | Georgia Tech | |||||
| 1963 | 21 | San Francisco 49ers | Walt Rock | G | Maryland | |||||
| 1962 | 21 | Chicago Bears | Bennie McRae | B | Michigan | |||||
| 1961 | 21 | Baltimore Colts | Tom Gilburg | T | Syracuse | |||||
| 1960 | 21 | Washington Redskins | Sam Horner | HB | Virginia Military | |||||
| 1959 | 21 | Chicago Bears | Richie Petitbon | QB | Tulane | |||||
| 1958 | 21 | Chicago Cardinals | Bobby Jack Oliver | T | Baylor | |||||
| 1957 | 21 | Washington Redskins | Joe Walton | E | Pittsburgh | |||||
| 1956 | 21 | Baltimore Colts | Dick Donlin | E | Hamline | |||||
| 1955 | 21 | San Francisco 49ers | Frank Morze | C | Boston College | |||||
| 1954 | 21 | Philadelphia Eagles | Rocky Ryan | E | Illinois | |||||
| 1953 | 21 | San Francisco 49ers | George Morris | C | Georgia Tech | |||||
| 1952 | 21 | Chicago Cardinals | Darrel Brewster | E | Purdue | |||||
| 1951 | 21 | Washington Redskins | Jim Staton | T | Wake Forest | |||||
| 1950 | 21 | Chicago Cardinals | Jack Jennings | T | Ohio State | |||||
| 1949 | 21 | Chicago Cardinals | Dick McKissack | B | SMU | |||||
| 1948 | 21 | Chicago Bears | Dub Garrett | T | Mississippi State | |||||
| 1947 | 21 | Los Angeles Rams | Don Paul | C | UCLA | |||||
| 1946 | 21 | Green Bay Packers | Bob Nussbaumer | HB | Michigan | |||||
| 1945 | 21 | Cleveland Rams | W.G. Wooten | E | Oklahoma | |||||
| 1944 | 21 | New York Giants | Clyde Flowers | T | TCU | |||||
| 1943 | 21 | New York Giants | Dewey Proctor | B | Furman | |||||
| 1942 | 21 | Washington Redskins | Rufus Deal | B | Auburn | |||||
| 1941 | 21 | Green Bay Packers | Bob Paffrath | B | Minnesota | |||||
| 1940 | 21 | Detroit Lions | Bill Fisk | E | USC | |||||
| 1939 | 21 | Chicago Bears | John Wysocki | E | Villanova | |||||
| 1938 | 21 | Detroit Lions | Pete Smith | E | Oklahoma | |||||
| 1937 | 21 | Philadelphia Eagles | Drew Ellis | T | TCU | |||||
| 1936 | 21 | Pittsburgh Pirates | Bobby Grayson | B | Stanford | |||||
NFL Draft - Overall Pick #21 Only