| Players Picked at #161 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2025 | 161 | Philadelphia Eagles | Smael Mondon Jr. | LB | Georgia | |||||
| 2024 | 161 | Washington Commanders | Dominique Hampton | S | Washington | |||||
| 2023 | 161 | Los Angeles Rams | Nick Hampton | LB | Appalachian State | |||||
| 2022 | 161 | New Orleans Saints | D'Marco Jackson | LB | Appalachian State | |||||
| 2021 | 161 | Buffalo Bills | Tommy Doyle | T | Miami (OH) | |||||
| 2020 | 161 | Tampa Bay Buccaneers | Tyler Johnson | WR | Minnesota | |||||
| 2019 | 161 | Houston Texans | Charles Omenihu | DE | Texas | |||||
| 2018 | 161 | Carolina Panthers | Jermaine Carter, Jr. | LB | Maryland | |||||
| 2017 | 161 | Indianapolis Colts | Anthony Walker Jr. | LB | Northwestern | |||||
| 2016 | 161 | Cincinnati Bengals | Christian Westerman | G | Arizona State | |||||
| 2015 | 161 | Oakland Raiders | Neiron Ball | LB | Florida | |||||
| 2014 | 161 | Green Bay Packers | Corey Linsley | C | Ohio State | |||||
| 2013 | 161 | Denver Broncos | Tavarres King | WR | Georgia | |||||
| 2012 | 161 | Houston Texans | Randy Bullock | K | Texas A&M | |||||
| 2011 | 161 | Philadelphia Eagles | Julian Vandervelde | G | Iowa | |||||
| 2010 | 161 | Minnesota Vikings | Chris DeGeare | T | Wake Forest | |||||
| 2009 | 161 | Miami Dolphins | John Nalbone | TE | Monmouth | |||||
| 2008 | 161 | Indianapolis Colts | Marcus Howard | DE | Georgia | |||||
| 2007 | 161 | Seattle Seahawks | Will Herring | LB | Auburn | |||||
| 2006 | 161 | Denver Broncos | Chris Kuper | G | North Dakota | |||||
| 2005 | 161 | New York Jets | Andre Maddox | S | North Carolina State | |||||
| 2004 | 161 | Cleveland Browns | Amon Gordon | DT | Stanford | |||||
| 2003 | 161 | San Francisco 49ers | Aaron Walker | TE | Florida | |||||
| 2002 | 161 | Miami Dolphins | Omare Lowe | S | Washington | |||||
| 2001 | 161 | Baltimore Ravens | Chris Barnes | RB | New Mexico State | |||||
| 2000 | 161 | New England Patriots | Jeff Marriott | G | Missouri | |||||
| 1999 | 161 | San Francisco 49ers | Tyrone Hopson | G | Eastern Kentucky | |||||
| 1998 | 161 | New Orleans Saints | Chris Bordano | LB | SMU | |||||
| 1997 | 161 | Detroit Lions | Duane Ashman | DE | Virginia | |||||
| 1996 | 161 | Arizona Cardinals | Harry Stamps | T | Oklahoma | |||||
| 1995 | 161 | Pittsburgh Steelers | Lance Brown | S | Indiana | |||||
| 1994 | 161 | Houston Oilers | Jim Reid | T | Virginia | |||||
| 1993 | 161 | San Diego Chargers | Eric Reid | S | Oregon | |||||
| 1992 | 161 | Chicago Bears | Mark Berry | DB | Texas | |||||
| 1991 | 161 | Chicago Bears | Darren Lewis | RB | Texas A&M | |||||
| 1990 | 161 | Los Angeles Rams | Tim Stallworth | WR | Washington State | |||||
| 1989 | 161 | Los Angeles Rams | Mark Messner | LB | Michigan | |||||
| 1988 | 161 | Chicago Bears | Lemuel Stinson | CB | Texas Tech | |||||
| 1987 | 161 | New York Jets | Tracy Martin | WR | North Dakota | |||||
| 1986 | 161 | Denver Broncos | Mark Jackson | WR | Purdue | |||||
| 1985 | 161 | Los Angeles Rams | Michael Young | WR | UCLA | |||||
| 1984 | 161 | Houston Oilers | Eric Mullins | WR | Stanford | |||||
| 1983 | 161 | Baltimore Colts | Grant Feasel | C | Abilene Christian | |||||
| 1982 | 161 | Miami Dolphins | Tom Tutson | DB | South Carolina State | |||||
| 1981 | 161 | Buffalo Bills | Robert Holt | WR | Baylor | |||||
| 1980 | 161 | Philadelphia Eagles | Greg Murtha | T | Minnesota | |||||
| 1979 | 161 | Pittsburgh Steelers | Dwayne Woodruff | DB | Louisville | |||||
| 1978 | 161 | Baltimore Colts | Ben Garry | RB | Southern Mississippi | |||||
| 1977 | 161 | Atlanta Falcons | Keith Jenkins | DB | Cincinnati | |||||
| 1976 | 161 | Chicago Bears | Dan Jiggetts | T | Harvard | |||||
| 1975 | 161 | Cleveland Browns | Merle Wang | T | TCU | |||||
| 1974 | 161 | Baltimore Colts | Noah Jackson | G | Tampa | |||||
| 1973 | 161 | Los Angeles Rams | Steve Brown | LB | Oregon State | |||||
| 1972 | 161 | Miami Dolphins | Bill Adams | G | Holy Cross | |||||
| 1971 | 161 | Philadelphia Eagles | Harold Carmichael | WR | Southern | HOF - 2020 | ||||
| 1970 | 161 | Buffalo Bills | Wayne Fowler | T | Richmond | |||||
| 1969 | 161 | Cincinnati Bengals | Royce Berry | DE | Houston | |||||
| 1968 | 161 | Los Angeles Rams | Bobby Webb | C | Southern Mississippi | |||||
| 1967 | 161 | Green Bay Packers | Bob Ziolkowski | T | Iowa | |||||
| 1966 | 161 | Washington Redskins | Dick Reding | WR | Northwestern State | |||||
| 1965 | 161 | Philadelphia Eagles | John Kuznieski | RB | Purdue | |||||
| 1964 | 161 | Los Angeles Rams | Bill Dawson | E | Florida State | |||||
| 1963 | 161 | San Francisco 49ers | Bob Benton | T | Mississippi State | |||||
| 1962 | 161 | Chicago Bears | Bill Watts | T | Miami (FL) | |||||
| 1961 | 161 | Baltimore Colts | Dick Reynolds | T | North Carolina State | |||||
| 1960 | 161 | Green Bay Packers | Jon Gilliam | C | Texas A&M-Commerce | |||||
| 1959 | 161 | Washington Redskins | Kurt Schwarz | G | Maryland | |||||
| 1958 | 161 | Chicago Bears | Bill Melnik | T | Army | |||||
| 1957 | 161 | Cleveland Browns | Don Feller | B | Kansas | |||||
| 1956 | 161 | Philadelphia Eagles | Frank Reich | C | Penn State | |||||
| 1955 | 161 | Green Bay Packers | Fred Baer | B | Michigan | |||||
| 1954 | 161 | New York Giants | Bobby Epps | B | Pittsburgh | |||||
| 1953 | 161 | Chicago Bears | Harland Carl | B | Wisconsin | |||||
| 1952 | 161 | Philadelphia Eagles | Bob Stringer | B | Tulsa | |||||
| 1951 | 161 | Green Bay Packers | Ray Bauer | E | Montana | |||||
| 1950 | 161 | Detroit Lions | Jim Ryan | B | San Francisco | |||||
| 1949 | 161 | Philadelphia Eagles | Frank Reno | E | West Virginia | |||||
| 1948 | 161 | Green Bay Packers | Ken Balge | E | Michigan State | |||||
| 1947 | 161 | Philadelphia Eagles | Hal Bell | B | Muhlenberg | |||||
| 1946 | 161 | Chicago Cardinals | Frank Irwin | T | Duke | |||||
| 1945 | 161 | Detroit Lions | Wayne Flanigan | E | Denver | |||||
| 1944 | 161 | Chicago Bears | Ed Hirsch | B | Northwestern | |||||
| 1943 | 161 | Detroit Lions | Chet Maeda | B | Colorado State | |||||
| 1942 | 161 | Pittsburgh Steelers | John Rokisky | E | Duquesne | |||||
| 1941 | 161 | Philadelphia Eagles | Joe McFadden | B | Georgetown (DC) | |||||
| 1940 | 161 | Chicago Cardinals | Lowell Bryant | B | Clemson | |||||
| 1939 | 161 | Pittsburgh Pirates | Dave Shirk | E | Kansas | |||||
