| Players Picked at #121 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2025 | 121 | Tampa Bay Buccaneers | David Walker | LB | Central Arkansas | |||||
| 2024 | 121 | Seattle Seahawks | A.J. Barner | TE | Michigan | |||||
| 2023 | 121 | Jacksonville Jaguars | Ventrell Miller | ILB | Florida | |||||
| 2022 | 121 | New England Patriots | Jack Jones | DB | Arizona State | |||||
| 2021 | 121 | Jacksonville Jaguars | Jordan Smith | OLB | Alabama Birmingham | |||||
| 2020 | 121 | Detroit Lions | Logan Stenberg | G | Kentucky | |||||
| 2019 | 121 | Tennessee Titans | Trevon Wesco | TE | West Virginia | |||||
| 2018 | 121 | Buffalo Bills | Taron Johnson | CB | Weber State | |||||
| 2017 | 121 | San Francisco 49ers | Joe Williams | RB | Utah | |||||
| 2016 | 121 | Minnesota Vikings | Willie Beavers | G | Western Michigan | |||||
| 2015 | 121 | Pittsburgh Steelers | Doran Grant | CB | Ohio State | |||||
| 2014 | 121 | Green Bay Packers | Carl Bradford | LB | Arizona State | |||||
| 2013 | 121 | Indianapolis Colts | Khaled Holmes | C | USC | |||||
| 2012 | 121 | Houston Texans | Keshawn Martin | WR | Michigan State | |||||
| 2011 | 121 | Jacksonville Jaguars | Chris Prosinski | S | Wyoming | |||||
| 2010 | 121 | Philadelphia Eagles | Keenan Clayton | LB | Oklahoma | |||||
| 2009 | 121 | Buffalo Bills | Shawn Nelson | TE | Southern Mississippi | |||||
| 2008 | 121 | Seattle Seahawks | Red Bryant | DT | Texas A&M | |||||
| 2007 | 121 | Denver Broncos | Marcus Thomas | DT | Florida | |||||
| 2006 | 121 | Carolina Panthers | Nate Salley | S | Ohio State | |||||
| 2005 | 121 | Carolina Panthers | Stefan LeFors | QB | Louisville | |||||
| 2004 | 121 | Dallas Cowboys | Bruce Thornton | CB | Georgia | |||||
| 2003 | 121 | Atlanta Falcons | Justin Griffith | FB | Mississippi State | |||||
| 2002 | 121 | New York Jets | Alan Harper | NT | Fresno State | |||||
| 2001 | 121 | Philadelphia Eagles | Correll Buckhalter | RB | Nebraska | |||||
| 2000 | 121 | Buffalo Bills | Avion Black | WR | Tennessee State | |||||
| 1999 | 121 | Jacksonville Jaguars | Kevin Landolt | T | West Virginia | |||||
| 1998 | 121 | Green Bay Packers | Roosevelt Blackmon | DB | Morris Brown | |||||
| 1997 | 121 | Miami Dolphins | Jerome Daniels | T | Northeastern | |||||
| 1996 | 121 | Philadelphia Eagles | Ray Farmer | LB | Duke | |||||
| 1995 | 121 | Denver Broncos | Jamie Brown | T | Florida A&M | |||||
| 1994 | 121 | New England Patriots | John Burke | TE | Virginia Tech | |||||
| 1993 | 121 | Atlanta Falcons | Ron George | LB | Stanford | |||||
| 1992 | 121 | Dallas Cowboys | Rod Milstead | G | Delaware State | |||||
| 1991 | 121 | Miami Dolphins | Gene Williams | G | Iowa State | |||||
| 1990 | 121 | Atlanta Falcons | Reggie Redding | T | Cal State-Fullerton | |||||
| 1989 | 121 | Miami Dolphins | Jeff Uhlenhake | C | Ohio State | |||||
| 1988 | 121 | Pittsburgh Steelers | Darin Jordan | ILB | Northeastern | |||||
| 1987 | 121 | Philadelphia Eagles | David Alexander | C | Tulsa | |||||
| 1986 | 121 | Philadelphia Eagles | Ray Criswell | P | Florida | |||||
| 1985 | 121 | Philadelphia Eagles | Dwayne Jiles | LB | Texas Tech | |||||
| 1984 | 121 | San Francisco 49ers | Michael Carter | DT | SMU | |||||
| 1983 | 121 | Detroit Lions | Steve Mott | C | Alabama | |||||
| 1982 | 121 | Houston Oilers | Malcolm Taylor | DE | Tennessee State | |||||
| 1981 | 121 | San Francisco 49ers | Lynn Thomas | DB | Pittsburgh | |||||
| 1980 | 121 | Minnesota Vikings | Doug Paschal | RB | North Carolina | |||||
| 1979 | 121 | Dallas Cowboys | Bob Hukill | G | North Carolina | |||||
| 1978 | 121 | Detroit Lions | Amos Fowler | G | Southern Mississippi | |||||
| 1977 | 121 | Pittsburgh Steelers | Cliff Stoudt | QB | Youngstown State | |||||
| 1976 | 121 | Tampa Bay Buccaneers | Richard Appleby | WR | Georgia | |||||
| 1975 | 121 | Denver Broncos | Rubin Carter | DT | Miami (FL) | |||||
| 1974 | 121 | New Orleans Saints | Terry Schmidt | DB | Ball State | |||||
| 1973 | 121 | Cincinnati Bengals | Bob McCall | RB | Arizona | |||||
| 1972 | 121 | New York Giants | Larry Edwards | LB | Texas A&I | |||||
| 1971 | 121 | St. Louis Cardinals | Rocky Wallace | LB | Missouri | |||||
| 1970 | 121 | Washington Redskins | Danny Pierce | RB | Memphis | |||||
| 1969 | 121 | Minnesota Vikings | Corny Davis | RB | Kansas State | |||||
| 1968 | 121 | Green Bay Packers | Steve Duich | G | San Diego State | |||||
| 1967 | 121 | San Diego Chargers | Bernard Erickson | LB | Abilene Christian | |||||
| 1966 | 121 | St. Louis Cardinals | Dan Goich | E | California | |||||
| 1965 | 121 | Los Angeles Rams | Ronnie Caveness | LB | Arkansas | |||||
| 1964 | 121 | St. Louis Cardinals | Willie Ross | B | Nebraska | |||||
| 1963 | 121 | Cleveland Browns | Dave Raimey | DB | Michigan | |||||
| 1962 | 121 | Baltimore Colts | Walt Rappold | QB | Duke | |||||
| 1961 | 121 | San Francisco 49ers | Evaristo DeLeon Nino | T | East Texas State | |||||
| 1960 | 121 | Los Angeles Rams | Ken Young | RB | Valparaiso | |||||
| 1959 | 121 | Green Bay Packers | Bob Webb | B | St. Ambrose | |||||
| 1958 | 121 | Detroit Lions | Elliot Schaubach | T | William & Mary | |||||
| 1957 | 121 | New York Giants | Gordon Massa | C | Holy Cross | |||||
| 1956 | 121 | Cleveland Browns | Eddie Rayburn | T | Rice | |||||
| 1955 | 121 | Cleveland Browns | Glen Dillon | E | Pittsburgh | |||||
| 1954 | 121 | Detroit Lions | Jack Carroll | E | Holy Cross | |||||
| 1953 | 121 | Detroit Lions | Dreher Gaskin | E | Clemson | |||||
| 1952 | 121 | Los Angeles Rams | Luke Welch | T | Baylor | |||||
| 1951 | 121 | Los Angeles Rams | Roland Kirkby | B | Washington | |||||
| 1950 | 121 | Green Bay Packers | Bob Mealey | T | Minnesota | |||||
| 1949 | 121 | Philadelphia Eagles | Dale Armstrong | E | Dartmouth | |||||
| 1948 | 121 | Green Bay Packers | Fred Provo | HB | Washington | |||||
| 1947 | 121 | Philadelphia Eagles | Alvin Johnson | B | Hardin-Simmons | |||||
| 1946 | 121 | Chicago Cardinals | Bob Russell | B | Miami (OH) | |||||
| 1945 | 121 | Chicago Cardinals | Elmore Luper | B | Duke | |||||
| 1944 | 121 | Chicago Cardinals | Bobby Dobbs | B | Tulsa | |||||
| 1943 | 121 | Detroit Lions | Ellard Dernoncourt | E | St. Louis | |||||
| 1942 | 121 | Pittsburgh Steelers | Clure Mosher | C | Louisville | |||||
| 1941 | 121 | Philadelphia Eagles | Les Dodson | B | Mississippi | |||||
| 1940 | 121 | Chicago Cardinals | Judson Hudson | B | Davis & Elkins | |||||
| 1939 | 121 | Pittsburgh Pirates | Ed Clary | B | South Carolina | |||||
